Matt Moore had a hand in two TDs for Miami, and Kevin Burnett returned an interception 34 yards for a score.
The surge by the Dolphins (4-8) comes after they lost their first seven games. In the past five games they've outscored opponents 139-54, with the lone loss a one-point defeat at Dallas on Thanksgiving.
For the Raiders (7-5), who began the day leading the AFC West, the drubbing ended a three-game winning streak. They fell to 6-25 in regular-season games in the Eastern Time Zone since December 2002.
The Dolphins put the game away with a 21-point third quarter.