Yasmin Acree went missing from her Austin-area home January 16, 2008. She was 15 years old at the time.
No one has been arrested in the case, and her family still hopes she will be found.
Family members and friends distributed flyers in the neighborhood Saturday afternoon.
"It's been four years, and it's been hard. It's been rough. Yasmin, maybe you can hear us. I want you to know that we love you and we miss you and we're doing our best to get you back," mother Rose Starnes said.
A $5,000 reward is being offered for information that leads to her safe return.