The fire was reported at 5:39 a.m., when thick smoke was seen coming from a home near 18th and Chestnut streets, according to the Oakland Fire Department.
Firefighters found someone trapped in the home and searched the residence for other victims while fighting the blaze, fire officials said.
Emergency crews performed CPR on the rescued person at the scene, according to the fire department.
Neighbors said the woman, who is in her early 90s, has died.
Lucille Howard, who lives across the street, said she went outside when she heard the fire trucks arrive and saw firefighters on top of the house "hacking on the roof" amid smoke.
Howard has lived in the neighborhood for 16 years and said the woman who died had lived there much longer. She said the woman would sometimes stand outside her home but that she hadn't seen her in a while.
Another neighbor, Mike Jeffries, said the woman had caretakers, and that his family would sometimes take her for walks.
bor, Mike Jeffries, said the woman had caretakers, and that his family would sometimes take her for walks.
He said his family has lived in the neighborhood for a long time, and that many people on that block know each other.