Oakland police followed the suspects as their black SUV weaved through traffic on the bridge, eventually crashing at the Fremont Street exit in San Francisco. Officials say at least three vehicles were involved in the crash.
The exit was shut down for a short time as police arrested the two men and crews cleaned up the scene.
The suspects suffered minor injuries and at least three other people were hurt in the crash.
Police say the men they were chasing are wanted for robbery and burglary.
