The robbery was reported at about 1:05 p.m. in the 2600 block of Ocean Avenue.
Two male suspects jumped over the bank counter and took cash from teller drawers before jumping back over the counter and fleeing on foot, police said.
No one was injured in the robbery and no weapons were seen. The suspects had not been found as of this morning, according to police.
Anyone with information about the robbery is encouraged to call the Police Department's anonymous tip line at (415) 575-4444 or to send a tip by text message to TIP411 with "SFPD" in the message.