The crash was reported at 8:34 p.m. on westbound Highway 4 near the Alhambra Avenue off-ramp.
At least three vehicles were involved and one person was killed.
Contra Costa County Fire Protection District officials said one other person suffered moderate injuries and a third suffered minor injuries in the crash.
All lanes of the highway are blocked as of 9 p.m. and there was no estimate for when they will be reopened, Ogilvie said.
The CHP is diverting westbound traffic off the highway at Alhambra Avenue.
Westbound CA-4 West of Alhambra Ave in Martinez, All Lanes Blocked Due to Accident. https://t.co/YHC7UzpBdB
— 511 Bay Area (@511SFBay) January 17, 2016