Pujols connected for the Los Angeles Angels in the first inning of Sunday's 9-2 loss to Kansas City.
"Obviously, it's a great accomplishment, man, but it's really disappointing," Pujols said. "We got swept by a great ballclub. I've told you guys my whole career, that at the end of my career I'm going to enjoy it a little bit more. But when I'm playing baseball, my goal is to try to help this ballclub to win."
Pujols' second homer of the season came off Yordano Ventura. The young Royals ace became the 334th different pitcher the three-time NL MVP and nine-time All-Star has homered against during his 15-year career.
Pujols' next target on the home run list is Jimmie Foxx at 534.
Information from The Associated Press was used in this report.
Pujols hits historic homer, but Angels get swept
Albert Pujols hit his 522nd home run to move into 18th place by himself on the career list, while Alcides Escobar had three RBIs in Kansas City's 9-2 win over Los Angeles.