Video from SKY7 shows a giant billboard on top of Nike's flagship just off Union Square.
TIMELINE: Looking back at Colin Kaepernick's transformation from football star to social justice advocate
The move comes a day after the company announced that Kaepernick would be a major part of its 30th anniversary "Just Do It" campaign.
The billboard features the caption, "Believe in something, even if it means sacrificing everything," which is a reference to Kaepernick's protests against racial injustice, that he and others believe has cost him a job in the NFL.
Get the latest on former 49er quarterback Colin Kaepernick here.
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