The suspect is described as an Asian female, 20- to 25-years-old with a small-to-medium build, and straight blonde hair that was cut long on the right side and short on the left and worn less than shoulder length, according to the Brisbane Police Department.
There were at least two other suspects in the vehicle at the time of the shooting, police said.
The incident began in San Francisco at about 2:30 a.m. when the victims, four men between 25 and 30 years old, were driving southbound on Highway 101 near Duboce Avenue and got into an altercation with the occupants of another vehicle, police Sgt. Robert Meisner said.
The alleged altercation continued on Highway 101 into the city of Brisbane, where the suspects' vehicle pulled up alongside the victims' vehicle and someone fired at least six rounds into the car, possibly with a 9mm handgun.
The driver and two passengers were struck, Meisner said.
Despite his injuries, the driver was able to pull to the side of the road, where someone in the car called for help.
The victims did not know the suspect and police were not sure what started the altercation.
The suspects' vehicle has been described as a white 2005 or 2006 Toyota Corolla with tinted windows, Meisner said.
Highway 101 was closed for more than two hours while police investigated the shooting, according to the California Highway Patrol.
Anyone who saw the shooting is asked to call police Detective Robert Guaydacan at (415) 559-0180 or the Brisbane Police Department at (415) 467-1212.
