The closure is scheduled as part of Caltrans and the Contra Costa Transportation Authority's project to widen Highway 4 through the area.
Westbound lanes of the highway will be closed from 10 p.m. Monday to 3:30 a.m. Tuesday.
Drivers will be detoured off the highway at the Somersville Road/Auto Center Drive exit in Antioch, where they will be directed to take a left onto Somersville Road. Somersville Road becomes Auto Center Drive. Drivers will then take a left onto 10th Street, a left onto Loveridge Road, a right onto California Avenue and a left back onto westbound Highway 4 in Pittsburg.
Drivers should expect delays and are urged to drive carefully, Caltrans officials said.
A similar closure conducted Wednesday went smoothly and didn't cause any major problems, said Jake Jones, an assistant public information officer for the project.