Javier Vazquez (10-10) allowed four hits in eight innings to help the White Sox win consecutive games in Oakland for the first time since August 2000. Chicago also took the season series from the A's for the first time in eight years.
Juan Uribe added a two-run shot and Jermaine Dye also homered as the White Sox won for the fifth time in six games to remain tied with Minnesota atop the AL Central. DeWayne Wise had an RBI for Chicago, which moved a season-best 17 games over .500 at 70-53.
Cliff Pennington doubled for his first major league hit and Daric Barton had an RBI single for the A's, who lost their fourth in five games.
Gio Gonzalez (1-2) was tagged for eight runs and six hits in 3 1-3 innings. The A's rookie, who walked five and struck out two, was making his third career start and was coming off his first victory. The A's have lost 10 straight series, falling to a major league-worst 5-23 since the All-Star break.
Quentin hit a two-run shot in the third, followed by Dye's homer. Ramirez's slam in the seventh made it 13-0.
Quentin, who took over the big league home run lead, finished the series with six hits in nine at-bats, driving in five and hitting a pair of homers. He was on base in 11 of his 14 plate appearances. The Stanford product had three hits in his first 24 career at-bats against the A's.
Vazquez, who had a 15-inning scoreless streak snapped when the A's scored in the eighth, also reversed a bad streak against the A's by winning his first game in Oakland in five starts. He also kept the ball from leaving the park for the first time in seven games against the A's.
The right-hander gave up 19 runs in his first 24 innings in Oakland.
Vazquez retired 13 of his first 14 batters. He struck out eight and did not walk a hitter as he moved into a tie with Al Leiter for 66th place on the career strikeout list at 1,974.