The crash affected the light rail line temporarily, but service is now getting back to normal. The crash happened around 8:00 am at Third Street and Fairfax Avenue.
Police say the LRV was going north, approaching the intersection of Third Street and Galvez when a Dodge stationwagon suddenly turned in front of it.
Darnisha Wright works nearby.
"We just heard this very incredibly loud smash and you could feel the impact on the building," said Wright.
SF Police Lieutenant Mike Favetti says the driver of the car appeared to have caused the accident.
"The car was moving at a high-rate of speed, so right now it looks like the car was at fault" said Favetti.
Eight passengers aboard the LRV were injured as well as two people in the station wagon.
"Of those 10 injuries, according the SF fire department, six were transported to area hospitals with what were reported as minor injuries," said Judson True, Muni spokesman.
The accident happened shortly after 8:00 am. The T-Third Street line was shut down for about an hour and a half as shuttle busses transported passengers.
It is unknown what the injuries are to the passengers in the car.
This is the third serious LRV accident in the past two days in San Francisco.