The puppy, a pit bull named Pogo, was exercising on Ocean Beach with his foster guardian from Grateful Dogs Rescue on July 22 when he disappeared.
Pogo was found stabbed to death a week later in a Dumpster in the Bayview, animal care officials said.
Anyone with information on Pogo's killing can call Animal Care and Control at (415) 554-9400.
Those who would like to contribute to the reward fund should call (415) 554-9413.