The crash was reported around 8:15 a.m. at 19th and Holloway avenues.
Sgt. Wilfred Williams said a 40-year-old San Francisco man was riding his motorcycle east on Holloway Avenue when he broadsided a Honda that was headed north on 19th Avenue. The motorcyclist was thrown about 20 feet, according to Williams.
Paramedics responded to the intersection and took the man to San Francisco General Hospital, where he succumbed to his injuries shortly before 9 a.m.
There was no immediate report of injuries to the 34-year-old San Francisco woman who was driving the Honda.
Williams said she stopped after the crash and no arrests were made in connection with the accident.
The crash affected traffic in the area for more than two hours this morning, but the intersection was cleared by 11:05 a.m., Williams said.
Ellen Griffin, a spokeswoman for SFSU, said the crash, which happened near the university's main entrance, but did not affect operations at the school.
"The university is always strongly concerned about safety on 19th Avenue and when accident like this occurs it heightens our awareness," she said.
Williams said the cause of the crash is under investigation.