The shooting, which police believe was gang-related, was reported at 1:30 a.m. at Linden and California avenues, police said.
Witnesses identified the suspect as 23-year-old Ariel Francisco Cabeza of South San Francisco and San Mateo, according to police.
Cabeza drives a silver 1990 Lincoln Town Car with a California license plate No. 6APP435. He is considered to be armed and dangerous, police said.
Anyone with information about the shooting or the whereabouts of Cabeza is urged to call the South San Francisco Police Department at (650) 877-8900.