The animal was spotted in some iceplant on I-880 just north of 66th Avenue shortly after 9:10 a.m., California Highway Patrol Officer Kevin Kroncke said.
A crew from the Marine Mammal Center was dispatched to rescue the sea lion, which had a large gash on its body, said Erin Brodie, the Marine Mammal Center's stranding coordinator.
The crew picked up the sea lion shortly before noon and arrived back at the Sausalito center about an hour later, Brodie said.
The Marine Mammal Center determined the animal's injuries were from a shark bite. The bite had paralyzed the sea lion and the decision was made to euthanize the animal.
BCN contributed to this story