Shawn Graves, 14, and Megan Singh, 12, were believed to be headed toward Nevada and might be either in Reno or Las Vegas by now, police said.
Megan is described as an Asian-Indian girl with black hair and black eyes. She is 5 feet 3 inches tall and weighs about 110 pounds.
Shawn is described as a white boy with blond hair and blue eyes. He is 5 feet 7 inches tall and weighs about 140 pounds.
Anyone who has seen either of them is asked to call the Richmond Police Department at (510) 620-6675.