Two 18-year-old men were hospitalized with head injuries sustained in the fight during the party attended by more than 200 people in the 2000 block of Dennis Lane in northwest Santa Rosa, Sgt. Rainer Navarro said.
One of the two men suffered non-life-threatening injuries and was admitted to the hospital, while the other was treated and released, Navarro said.
The assault suspects fled the party before police arrived around 10:30 p.m.
Anyone with information about the assault is asked to call police at (707) 543-3670.