The department received a call at 2:52 a.m. of an accident at 41st Avenue and Cabrillo Street.
All four victims were transported to San Francisco General Hospital, with one victim shuttled at 3:09 a.m. and the remaining three victims transported at 3:20 a.m., the dispatcher said.
No information about the extent of their injuries or the nature of the crash was available as of 3:30 a.m.