The solo-vehicle crash was reported at about 7:45 a.m. near the off-ramp to Blossom Hill Road from southbound Highway 101, California Highway Patrol Officer Eric Anderson said.
The vehicle went off the roadway and struck a tree near the right hand shoulder, Anderson said.
Two woman were killed in the crash, while a third person in the car was taken to a local hospital where they were reportedly in stable condition, according to the medical examiner's office.
The medical examiner's office was working this afternoon on identifying the two women who died and notifying their families.
The crash caused the closure of the Blossom Hill Road off-ramp for nearly four hours. It was reopened at about 11:30 a.m.