Officers responded to reports of a stabbing at Mission and Norton streets at around 2:20 a.m., San Francisco police Officer Albie Esparza said.
Two men in their mid 20s were reportedly walking on Mission Street when they were attacked and each stabbed multiple times by an unknown number of suspects, Esparza said.
The two victims were taken to San Francisco General Hospital and are expected to survive their injuries.
Police were trying to identify possible suspects as of Sunday morning.
Anyone who witnessed the stabbing is urged to call the San Francisco police anonymous tip line at (415) 575-4444.