Fire crews found the home on Valley Drive fully engulfed in flames when they arrived at the scene just after 7 p.m.
The fire destroyed severael cars in the driveway and caused some damage to a neighborhing home.
Three residents of the home were taken to a local hospital after inhaling smoke.
The Contra Costa County fire marshall says a smoke alarm alerted residents to the fire. It's believed the blaze started in the garage of the home.
At times, the fire was so intense that it sent up a large column of smoke that could be seen from more than a mile away.