The robbery was reported at about 2:40 a.m. in the 700 block of Ellis Street.
A 21-year-old woman went to answer a sound at the door, and four suspects stormed in when she opened the door, according to police.
A suspect held the woman down on a bed while a 25-year-old man also inside the home was held against a wall by another suspect, police said.
The other two suspects took property from the home, including a laptop, a wallet and cash. The four suspects then fled and had not been found as of this morning, according to police.
The man and woman were both uninjured in the robbery. A third person in the home slept through the incident, police said.
Anyone with information about the case is encouraged to call the Police Department's anonymous tip line at (415) 575-4444 or send a tip by text message to TIP411.