The stabbing was reported at 12:43 a.m. in the 2100 block of Mission Street near 17th Street.
Police said two suspects approached the 26-year-old victim and an argument ensued, according to police. The argument turned physical, and the victim was stabbed in the abdomen, police said.
The victim was taken to San Francisco General Hospital. Police did not have an update on his condition this morning.
The suspects, men in their early or mid-20s, fled after the stabbing and remain at large. Anyone with information about the stabbing is asked to call the Police Department's anonymous tip line at (415) 575-4444 or send a tip by text message to TIP411.