The robbery was reported at about 6 a.m. Thursday at a business in the 1700 block of Ocean Avenue, police Sgt. Mike Andraychak said.
Two suspects walked into the cafe and each pulled out handguns and demanded money, police said.
A 48-year-old man in the business handed over an undisclosed amount of cash to the suspects, who then fled on foot, according to police.
The suspects, both men believed to be between 25 and 30 years old, had not been found as of today, police said.
No one was injured during the robbery.
Anyone with information about the case is encouraged to call the Police Department's anonymous tip line at (415) 575-4444 or send a tip by text message to TIP411.