Police received a report of a person shot in the 400 block of South Kiely Boulevard at 9:01 p.m.
Upon arrival, police located the victim outside a 7-Eleven store.
The victim was pronounced deceased at the scene.
The suspects fled the scene prior to the arrival of police on the scene. Police are investigating the motive for the shooting and searching for suspects.
Friday night's fatal shooting marks San Jose's 42nd homicide in 2012, according to police.