It broke out just before 7 a.m. in the attic at of Taqueria Lorena at 399 S. 24th Street.
A captain says firefighting efforts were briefly hampered by electrical wires.
Damage was contained to the roof and attic, but water damaged parts of the main business.
The restaurant had not yet opened for the day. There were no injuries.
The cause of the fire is under investigation.