The sole victim in the crash has been identified as Alma Cabrera-Villar, 20, of Redwood City, according to the San Mateo County coroner's office.
The crash was reported at 4:17 a.m. near 1757 E. Bayshore Road, police said.
The road reopened at 8:06 a.m., police said.
Redwood City police shut down traffic in both directions while the fatal accident was investigated.