The crash happened at about 4:50 p.m. near the East Blithedale Avenue exit.
CHP Officer Peter Van Eckhardt said that a few minutes before the crash, the CHP received word that the Central Marin Police Authority was chasing a suspect on the highway.
The chase ended when the suspect crashed into the back of the school bus, he said.
The bus was not carrying any children and the bus driver was not injured, CHP Officer Andrew Barclay said.
The suspect was taken into custody at the scene, he said.
The bus was disabled in the crash and was blocking the No. 4 and 5 southbound lanes, Van Eckhardt said. The lanes were still blocked as of 5:30 p.m. but were expected to be cleared shortly.