Hospital spokesperson Rachael Kagan said the victim had been in critical condition and succumbed to her injuries Friday morning.
One doctor said he did, "everything we could to take care of this young lady."
Officials say the girl's family has requested that no details be released about her or the injuries she sustained in the crash. Though a source has confirmed to ABC7 News that the girl is Chinese.
San Francisco General Hospital is still treating six patients, five adults and a child, who were injured in the crash at the airport on Saturday.
Kagan says two of those patients, both adults, remain in critical condition with injuries that include spinal cord and abdominal trauma, road rash and bone fractures. The other four patients' conditions range from serious to fair to good.
According to Kagan, the hospital has handled a total of 67 patients who were injured in the crash.
SFPD: Teen struck by fire truck after SFO crash
San Francisco police have confirmed that a fire truck hit one of the two girls who died in the plane crash at San Francisco International Airport. The San Mateo County coroner has not determined what the girl's cause of death was.
Ye Meng Yuan, 16, was on the ground and covered in foam that had been sprayed by fire crews. When the truck moved while battling the flames, rescuers discovered her body in the tire track.
It may take the coroner two or three more weeks to determine her cause of death. The fire department is cooperating with all the agencies investigating death.
Thick smoke at crash site overnight
Overnight, thick smoke could be seen from site of the Asiana Airlines plane wreckage at San Francisco International Airport. The thick white smoke could be seen as crews worked to move debris from the plane. ABC7 News is now being told there was no fire, just heavy smoke caused by metal friction as crews cut the plane into smaller pieces.
"When we do this it's cutting through metal, it's creates a lot of friction, a lot heat. We had reports of smoke but no fire. We did have a fire crew standing by during the entire process and they were quickly able to put out that smoke," said Airport spokesman Doug Yakel.
Moments before the heavy smoke, the back part of the aircraft was lifted with a sling and debris came spilling out.
"We really didn't know what to expect. We didn't know if we were going to be able to move it. We didn't know how the wreckage would react to being lifted, if it would buckle. So there were a lot of things we didn't know, there were a lot of things that could have gone wrong," said Yakel.
The plane was removed from the runway and has been placed near the United Airlines hangar. Airport officials said it will remain in that spot for a week or two while the airline decides what to do with it.
"The NTSB has gathered all of the pieces that they need for their investigation, so these remaining elements are essentially the property of the airline," said Yakel.
Work has started on repaving the runway and fixing the light system damaged in the crash. Crews hope to have the runway reopened by Sunday night.
Speier, Pelosi visit crash site
Thursday night Rep. Jackie Speier, D-San Mateo, House Minority Leader Nancy Pelosi, D-Calif., San Francisco Mayor Ed Lee, and San Francisco Fire Chief Joanne Hayes-White visited the crash site.
Speier and Pelosi were at SFO after they returned from Washington D.C. and they wanted to take a look at the wreckage. They wanted to thank the first responders, the airport, and the city so they paid tribute to San Francisco Mayor Ed Lee, San Francisco Fire Chief Joanne Hayes-White and NTSB Chair Deborah Hersman. Speier said seeing the wreckage Thursday night was jarring.
"You see how much destruction there is and to think that 302 passengers got out and the staff and the flight attendants, it's really… it's a miracle," said Speier.
"The miracle was served by science and technology, that was what enabled many lives to be saved. What public policy can accompany that to save lives in the future," said Pelosi.
Pelosi really wants to find out what lawmakers can do in cooperation with federal and local authorities to make sure that something like this doesn't happen in the future.
(The Associated Press and Bay City News contributed to this report.)