Shortly after 6 p.m. on Friday, police responded to a residence on Ashford Court, near Yorkshire Drive, on a report of a marijuana grow operation.
Officers arrived at the home and confirmed the large-scale marijuana cultivation, police said.
Investigators seized about 442 marijuana plants along with marijuana cultivation equipment from the home, according to police.
Officers have not released any information about who was running the operation or if any suspects have been arrested.
Anyone with information regarding this case is encouraged to call Detective Mortimer with the Antioch Police Department at (925) 779-6941.