The two-vehicle crash was reported at about 3:10 p.m., north of the Hegenberger Road on-ramp and just south of the Oakland Coliseum, the CHP said.
One person died at the scene and another person was injured and has been transported to a hospital, according to the CHP.
The CHP is investigating reports that a person attempted to flee the scene on foot following the crash.
A Sig-alert was issued shortly after 3:30 p.m. and canceled at about 5:15 p.m., according to the CHP.
The identity of the person killed has not been released and the cause of the collision remains under investigation.
