The FBI said authorities seized 20 pounds of the drug with an estimated street value of more than $900,000.
Authorities received information in July about the narcotics distribution network operating in Sonoma County and conducted an investigation, the FBI said.
Rohnert Park and Santa Rosa police, the Sonoma County Sheriff's Department and the U.S. Drug Enforcement Administration joined the FBI investigation.
Authorities arrested Miguel Gutierrez Valdez, 30, of Rohnert Park; Guillermo Enrique Reyna, 36, of Santa Rosa; and Jubenal Amezola Jr., 37, and Jorge Luis Sanchez, 28, both of Southern California. They are being held pending a detention hearing Dec. 12 in federal court in San Francisco.
DEA Special Agent Casey McEnry said Valdez ran the high-quality crystal "ice" distribution ring and that 20 pounds of methamphetamine were found in his apartment on Camino Colegio in Rohnert Park Thursday afternoon.
The source of the drugs was in Southern California, McEnry said.
The defendants face 10 years in prison if convicted, the FBI said.