Boone became heavily involved in the zoo in the fall of 2012 and has since created the Alex Boone Animal Education Project to bring local at-risk youth to the zoo, officials at the zoo said.
To honor him for his efforts, the rhino has been named "Boone."
"There are very few black rhinos left on this planet, so to have one named after me is truly an honor," Boone said in a statement.
There will be a VIP event beginning at 2 p.m. at the Nature Exploration Meadow, followed by a public event in which the 49ers offensive lineman will feed the rhino and unveil a plaque, zoo officials said.
The 49ers' Gold Rush cheerleaders and the team's mascot Sourdough Sam will also be in attendance.