A growing number of states -- including Connecticut, Illinois, Kentucky, Nevada, Oregon, Pennsylvania and Washington state -- said they would change their rules to follow the agency's new guidance, hours after it was announced.
However, Hawaii and Massachusetts announced that for now, they plan to keep their mask mandates in place. Over a dozen other states and jurisdictions have yet to announce their plans.
Local leaders in Massachusetts, New York, New Jersey, California, and Washington, D.C., which are all led by Democrats, said Thursday they'd take the new CDC guidance under advisement before adopting.
Whether states that choose to follow CDC guidelines will keep their mask mandates in place for unvaccinated individuals, remains unclear.
"If you are fully vaccinated, you can start doing the things that you had stopped doing because of the pandemic," CDC Director Rochelle Walensky said at a White House briefing Thursday.
The CDC said locals must continue to abide by existing state and local regulations and business rules. The new guidance comes on the heels of the CDC's approval of the COVID-19 vaccine for 12- to 15-year-olds on Wednesday.
Currently, 22 state governments, as well as Washington, D.C., and Puerto Rico, require people to wear face coverings in public settings.
The pandemic saw local leaders impose restrictions upon their constituents, with many of the most stringent lockdowns ordered by Democratic leaders.
On Friday, Minnesota and North Carolina ended their mask mandates.
North Carolina Gov. Roy Cooper lifted all mandatory capacity, gathering limits and social distancing requirements while easing most mask requirements. The state will follow the new CDC guidance and masks will be required in child care, schools and camps as most children are not vaccinated or not eligible to be vaccinated yet.
Michigan, Maryland and Virginia also joined the other states in lifting mask requirements for vaccinated locals.
Michigan Gov. Gretchen Witnmer updated the state's mask mandate following the CDC guidance, ahead of the state's July 1 mask mandate expiration date.
Maryland Gov. Larry Hogan lifted the state's indoor and outdoor mask mandate effective Saturday.
"Today is the day that so many of us have been waiting for and working toward," Hogan said. "We finally do clearly see the light at the end of that tunnel. Our long, hard-fought battle against the worst global pandemic in more than a century is finally nearing an end."
In Maine, officials said they'd adopt the new CDC guidance effective May 24.
At a city level, mayors in Washington, D.C., and New York City are reviewing the guidance before announcing any official changes. Mayor Bill de Blasio said Thursday the city will review the new rules "as masks will still be important for schools, public transportation, doctors' offices and more."
Similarly, the Los Angeles County Department of Public Health said "L.A. County and the state will review the recommendations in order to make sensible adjustments." Gov. Gavin Newsom said this week the state would drop outdoor mask mandates on June 15, when the state intends to fully reopen.
In Washington state, Gov. Jay Inslee didn't wear a mask for his news conference Thursday saying the state was immediately adopting the new federal guidance on mask wearing.
"This is a really good reason to get vaccinated. That shot is a ticket to freedom from masks," Inslee said.
States that haven't announced a new guidance yet include California, New Jersey, New York, D.C. and Puerto Rico as of Saturday.
The new recommendation, which carves out exceptions for buses, planes, trains, hospitals, prisons and homeless shelters, will havesignificant implicationsfor schools and businesses as the country begins to reopen.
Even on Capitol Hill, lawmakers must abide by the mask guidance until all House staffers are vaccinated, according to a memo by the office of the attending physician obtained by ABC News.
Some critics wonder if the decision comes too hastily as variants still threaten the spread of COVID-19 and several regions of the country still grapple with vaccine hesitancy.
So far, 35.8% of the U.S. population is fully vaccinated, or more than 118 million people. That number is projected to surge now that children are eligible for the vaccine.