The victim was shot several times inside a car near 23rd Street and San Jose Avenue.
When police arrived on scene they found the victim with life-threatening injuries and he was taken to the hospital.
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Police say the victim was a 36-year-old male.
No arrests have been made.
Anyone with information regarding this case is asked to contact the San Francisco Police Department's 24-hour-tip line at 1-415-575-4444.