Officers responded to the crash at about 1 a.m. at 19th Avenue and Kirkham Street in the city's Sunset District, according to officials.
The vehicle with the two males initially collided with another vehicle traveling on 19th Avenue, police said.
After crashing into that vehicle, the males' vehicle jumped the roadway's median and first slammed into a parked car, and then into a house, according to officials.
Both males in that vehicle were reportedly transported to San Francisco General Hospital. The vehicle's driver suffered a cut to his head and was listed in stable condition, and the passenger endured bruising on his arm, according to officials.
No other injuries were reported, police said.
