The fatal crash was reported around 1:15 p.m. on westbound Highway 80 near the Carlson Boulevard exit, according to the California Highway Patrol.
The CHP is reporting that a black car was heading west on Highway 80 when it crashed into the roadway's center divider, also hitting multiple other cars along the way.
One car involved in the crash overturned.
The CHP issued a Sig-alert for the crash at 1:33 p.m., closing all lanes and re-routing traffic. All lanes reopened around 4:30 p.m.
(ABC7 News contributed to this report)